Please use this identifier to cite or link to this item: http://cibnor.repositorioinstitucional.mx/jspui/handle/1001/2281
White spot syndrome virus down-regulates expression of histones H2A and H4 of Penaeus vannamei to promote viral replication
TRINIDAD ENCINAS GARCIA
José Fernando Mendoza Cano
Alberto Peña Rodríguez
DIANA FIMBRES OLIVARRIA
Enrique de la Re Vega
José Arturo Sánchez Paz
Acceso Abierto
Atribución-NoComercial-SinDerivadas
DOI: 10.3354/dao03428
URL: https://www.int-res.com/abstracts/dao/v137/n1/p73-79/
ISSN: 1616-1580
WSSV, Histones, H2A, H4, Immune evasion, Viral replication
"The white spot syndrome virus (WSSV) is a highly lethal and contagious pathogen to most cultivated shrimp species. The WSSV genome contains the ICP11 gene and its encoded protein acts as a multifunctinal DNA mimic protein that disrupts the nucleosome assembly by binding to the histone proteins H2A and H3. In addition, WSSV provokes severe nuclear hypertrophy and DNA damage. However, little is known about the influence of WSSV on the expression of the host’s genes encoding for histones. Therefore, we investigated the effect of WSSV infection on the expression of the genes encoding histones in shrimp Penaeus vannamei. An RT-qPCR assay was performed to evaluate the temporal expression of H2A and H4 transcripts in the shrimp. Significant changes were observed in the expression of these genes, which coincided with the dynamics of replication of the virus. H2A reached its maximum expression levels at 12 hpi. Thus, it may be suggested that this is a viral strategy to evade the host’s immune response in order to promote viral replication."
Inter Research
2019
Artículo
DISEASES OF AQUATIC ORGANISMS
Inglés
Encinas-García T, Loreto-Quiroz DL, Mendoza-Cano F, Peña-Rodriguez A, Fimbres-Olivarria D, de la Re-Vega E, Sánchez-Paz A (2019) White spot syndrome virus down-regulates expression of histones H2A and H4 of Penaeus vannamei to promote viral replication. Dis Aquat Org 137:73-79. https://doi.org/10.3354/dao03428
VIROLOGÍA ANIMAL
Versión publicada
publishedVersion - Versión publicada
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