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http://cibnor.repositorioinstitucional.mx/jspui/handle/1001/2758| Evolution of a Genetic Incompatibility in the Genus Xiphophorus | |
| Samuel Scarpino Patrick J. Hunt FRANCISCO JAVIER GARCIA DE LEON Thomas Juenger Manfred Schartl Mark Kirkpatrick | |
| Acceso Abierto | |
| Atribución-NoComercial-SinDerivadas | |
| DOI: https://doi.org/10.1093/molbev/mst127 URL: https://academic.oup.com/mbe/article/30/10/2302/1244868 ISSN: 15371719 | |
| genetic incompatibility, phylogenetic analysis, coevolution, Xiphophorus | |
| "Genetic incompatibilities are commonly observed between hybridizing species. Although this type of isolating mechanism has received considerable attention, we have few examples describing how genetic incompatibilities evolve. We inves- tigated the evolution of two loci involved in a classic example of a Bateson–Dobzhansky–Muller (BDM) incompatibility in Xiphophorus, a genus of freshwater fishes from northern Central America. Hybrids develop a lethal melanoma due to the interaction of two loci, an oncogene and its repressor. We cloned and sequenced the putative repressor locus in 25 Xiphophorus species and an outgroup species, and determined the status of the oncogene in those species from the literature. Using phylogenetic analyses, we find evidence that a repeat region in the proximal promoter of the repressor is coevolving with the oncogene. The data support a hypothesis that departs from the standard BDM model: it appears the alleles that cause the incompatibilities have coevolved simultaneously within lineages, rather than in allopatric or temporal isolation." | |
| Oxford University Press | |
| 2013 | |
| Artículo | |
| Molecular Biology and Evolution | |
| Inglés | |
| Samuel V. Scarpino and others, Evolution of a Genetic Incompatibility in the Genus Xiphophorus, Molecular Biology and Evolution, Volume 30, Issue 10, October 2013, Pages 2302–2310, https://doi.org/10.1093/molbev/mst127 | |
| GENÉTICA ANIMAL | |
| Versión publicada | |
| publishedVersion - Versión publicada | |
| Aparece en las colecciones: | Artículos |
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