Please use this identifier to cite or link to this item: http://cibnor.repositorioinstitucional.mx/jspui/handle/1001/1568
Prospects on the Use of Schizochytrium sp. to Develop Oral Vaccines
Abel Antonio Ramos Vega
SERGIO ROSALES MENDOZA
BERNARDO BAÑUELOS HERNANDEZ
Carlos Eliud Angulo Valadez
Acceso Abierto
Atribución-NoComercial-SinDerivadas
DOI: 10.3389/fmicb.2018.02506
ISSN: 1664302X
URL: https://www.frontiersin.org/articles/10.3389/fmicb.2018.02506/full
adjuvant, bioencapsulation, microalgae, oral vaccine, thermostable vaccine, Algevir system
"Although oral subunit vaccines are highly relevant in the fight against widespread diseases, their high cost, safety and proper immunogenicity are attributes that have yet to be addressed in many cases and thus these limitations should be considered in the development of new oral vaccines. Prominent examples of new platforms proposed to address these limitations are plant cells and microalgae. Schizochytrium sp. constitutes an attractive expression host for vaccine production because of its high biosynthetic capacity, fast growth in low cost culture media, and the availability of processes for industrial scale production. In addition, whole Schizochytrium sp. cells may serve as delivery vectors; especially for oral vaccines since Schizochytrium sp. is safe for oral consumption, produces immunomodulatory compounds, and may provide bioencapsulation to the antigen, thus increasing its bioavailability. Remarkably, Schizochytrium sp. was recently used for the production of a highly immunoprotective influenza vaccine. Moreover, an efficient method for transient expression of antigens based on viral vectors and Schizochytrium sp. as host has been recently developed. In this review, the potential of Schizochytrium sp. in vaccinology is placed in perspective, with emphasis on its use as an attractive oral vaccination vehicle."
Frontiers Media, S.A.
2018
Artículo
Frontiers in Microbiology
Inglés
Ramos-Vega A, Rosales-Mendoza S, Bañuelos-Hernández B and Angulo C (2018) Prospects on the Use of Schizochytrium sp. to Develop Oral Vaccines. Front. Microbiol. 9:2506. doi: 10.3389/fmicb.2018.02506
VACUNAS
Versión publicada
publishedVersion - Versión publicada
Appears in Collections:Artículos

Upload archives


File SizeFormat 
PUB-ARTICULO-4226.PDF739.8 kBAdobe PDFView/Open