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http://cibnor.repositorioinstitucional.mx/jspui/handle/1001/761| The Neuroprotective Effect of Erythropoietin in Rat Hippocampus in an Endotoxic Shock Model | |
| TANIA ZENTENO SAVIN BLANCA MIRIAM DE GUADALUPE TORRES MENDOZA OSCAR KURT BITZER QUINTERO Luis Javier Ramírez Jirano Ramón Gaxiola Robles Elsy Janeth Ramos González | |
| Acceso Abierto | |
| Atribución-NoComercial-SinDerivadas | |
| ISSN: 2564-8896 URL: http://clinicalandtranslationalinvestigation.com | |
| Erythropoietin, Endotoxic shock, Neuroimmunology, Neuroinflammation, Oxidative stress | |
| "Sepsis is characterized by an early systemic inflammation in response to infection. In the brain, inflammation is associated with expression of pro-inflammatory cytokines (e.g. tumor necrosis factor-α, interleukin-1β and interleukin-6, among others) that may induce an overproduction of reactive oxygen and nitrogen species. The constitutive expression of cytokines in the brain is low, but may be induced by various stimuli, including lipopolysaccharide, which causes neuronal damage. Erythropoietin, among other effects, acts as a multifunctional neurotrophic factor implicated in neurogenesis, angiogenesis, vascular permeability, and immune regulation in the central nervous system. In an experimental model of endotoxic shock, we studied the neuroprotective capacity of erythropoietin in the rat hippocampus and compared with melatonin, a neurohormone with an important antioxidant and immunomodulatory effect. Methods: In 21-day-old male Wistar rats divided into eight groups, we administered by intraperitoneal injection lipopolysaccharide, erythropoietin, melatonin, or combinations thereof. The hippocampus was dissected and morphological (histological analysis) and biochemical (cytokine levels) studies were conducted. Results: The number of dead neuronal cells in histological sections in groups treated with lipopolysaccharide was higher compared to the erythropoietin group. There was a greater decrease (70%) in interleukin-1β concentrations in rats with endotoxic shock that received erythropoietin compared to the lipopolysaccharide group." | |
| Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán | |
| 2016 | |
| Artículo | |
| REVISTA DE INVESTIGACIÓN CLÍNICA | |
| Inglés | |
| NEUROPATOLOGÍA | |
| Versión publicada | |
| publishedVersion - Versión publicada | |
| Aparece en las colecciones: | Artículos |
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