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http://cibnor.repositorioinstitucional.mx/jspui/handle/1001/2281| White spot syndrome virus down-regulates expression of histones H2A and H4 of Penaeus vannamei to promote viral replication | |
| TRINIDAD ENCINAS GARCIA José Fernando Mendoza Cano Alberto Peña Rodríguez DIANA FIMBRES OLIVARRIA Enrique de la Re Vega José Arturo Sánchez Paz | |
| Acceso Abierto | |
| Atribución-NoComercial-SinDerivadas | |
| DOI: 10.3354/dao03428 URL: https://www.int-res.com/abstracts/dao/v137/n1/p73-79/ ISSN: 1616-1580 | |
| WSSV, Histones, H2A, H4, Immune evasion, Viral replication | |
| "The white spot syndrome virus (WSSV) is a highly lethal and contagious pathogen to most cultivated shrimp species. The WSSV genome contains the ICP11 gene and its encoded protein acts as a multifunctinal DNA mimic protein that disrupts the nucleosome assembly by binding to the histone proteins H2A and H3. In addition, WSSV provokes severe nuclear hypertrophy and DNA damage. However, little is known about the influence of WSSV on the expression of the host’s genes encoding for histones. Therefore, we investigated the effect of WSSV infection on the expression of the genes encoding histones in shrimp Penaeus vannamei. An RT-qPCR assay was performed to evaluate the temporal expression of H2A and H4 transcripts in the shrimp. Significant changes were observed in the expression of these genes, which coincided with the dynamics of replication of the virus. H2A reached its maximum expression levels at 12 hpi. Thus, it may be suggested that this is a viral strategy to evade the host’s immune response in order to promote viral replication." | |
| Inter Research | |
| 2019 | |
| Artículo | |
| DISEASES OF AQUATIC ORGANISMS | |
| Inglés | |
| Encinas-García T, Loreto-Quiroz DL, Mendoza-Cano F, Peña-Rodriguez A, Fimbres-Olivarria D, de la Re-Vega E, Sánchez-Paz A (2019) White spot syndrome virus down-regulates expression of histones H2A and H4 of Penaeus vannamei to promote viral replication. Dis Aquat Org 137:73-79. https://doi.org/10.3354/dao03428 | |
| VIROLOGÍA ANIMAL | |
| Versión publicada | |
| publishedVersion - Versión publicada | |
| Aparece en las colecciones: | Artículos |
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| Diseases of Aquatic Organisms 2019 vol 137.pdf | 190.86 kB | Adobe PDF | Visualizar/Abrir |