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http://cibnor.repositorioinstitucional.mx/jspui/handle/1001/1072| Estrogen Repression of MicroRNAs Is Associated with High Guanine Content in the Terminal Loop Sequences of Their Precursors | |
| MARIO ALBERTO BURGOS ACEVES Tamar Kahan | |
| Acceso Abierto | |
| Atribución-NoComercial-SinDerivadas | |
| DOI: 10.3390/biomedicines5030047 ISSN: 2227-9059 URL: http://www.mdpi.com/journal/biomedicines | |
| estrogen, microRNA, Terminal loop, Guanine, cigarette smoke, xenoestrogens, DNA adducts, cancer | |
| "Widespread microRNA (miRNA) repression is a phenomenon observed in mammals after exposure to cigarette smoke and in many types of cancer. A comprehensive reduction in miRNA expression after treatment with the hormone estrogen has also previously been described. Here, we reveal a conserved association of miRNA downregulation after estrogen exposure in zebrafish, mouse, and human breast cancer cell line, with a high guanine content in the terminal loop sequences of their precursors, and offer a possible link between estrogen-related miRNA-adducts formation and carcinogenesis. We also show common gene expression patterns shared by breast cancer tumors and estrogen-treated zebrafish, suggesting that this organism can be used as a powerful model system for the study of human breast cancer." | |
| Multidisciplinary Digital Publishing Institute | |
| 2017 | |
| Artículo | |
| Biomedicines | |
| Inglés | |
| Cohen, A.; Burgos-Aceves, M.A.; Kahan, T.; Smith, Y. Estrogen Repression of MicroRNAs Is Associated with High Guanine Content in the Terminal Loop Sequences of Their Precursors. Biomedicines 2017, 5, 47. | |
| ONCOLOGÍA | |
| Versión publicada | |
| publishedVersion - Versión publicada | |
| Aparece en las colecciones: | Artículos |
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| cohen_a2017vol5(3).pdf | 2.65 MB | Adobe PDF | Visualizar/Abrir |